The McMackin Lab harnesses MRI and electrophysiological methods such as transcranial magnetic stimulation (TMS), electromyography (EMG), and electroencephalography (EEG) to understand and develop clinically meaningful measurements of neurological diseases, including Amyotrophic Lateral Sclerosis/ Motor Neurone Disease and Huntington's Disease. The Lab also performs research to understand the basic human physiology underpinning the electrophysiology-based measures, to improve the correct understanding and application of these measures.